The association of rs710886 in lncRNA PCAT1 with bladder cancer risk in a Chinese population

作者：Lin, Yadi; Ge, Yuqiu; Wang, Yunyan; Ma, Gaoxiang; Wang, Xiaowei; Liu, Hanting; Wang, Meilin; Zhang, Zhengdong^*; Chu, Haiyan^*

来源：Gene, 2017, 627: 226-232.

DOI：10.1016/j.gene.2017.06.021

• PCAT1
• lncRNA
• Genetic variation
• Bladder cancer
• Molecular epidemiology

Objective: The long noncoding RNA PCAT1 is an important gene involved in urinary tumors. In this study, we aimed to explore the association between polymorphisms in PCAT1 and bladder cancer susceptibility. @@@ Methods: A two-stage case-control study was conducted to assess the association between four tagging SNPs (i.e., rs4871771, rs1902432, rs16901904 and rs710886) and bladder cancer risk. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with unconditional univariate and multivariate logistic regression. @@@ Results: At the first stage of discovery, we identified that SNP rs710886A > G was significantly associated with bladder cancer risk (OR = 0.86, 95% CI = 0.74-0.99, P = 0.046). At the following stage of validation, individuals with GG genotype were found to have a significant reduction in bladder cancer risk compared with those carrying AA genotype (adjusted OR = 0.83, 95% CI = 0.74-0.93, P = 0.001). Furthermore, stratified analyses showed that protective effect of rs710886 was more pronounced in subgroup of age > 60 and never smoking, and had little to do with sex. Besides, rs710886 was identified as an eQTL for PCAT1. G allele was consistent with lower PCAT1 expression. @@@ Conclusion: This study indicates that genetic variants in lncRNA PCAT1 were associated with bladder cancer susceptibility and the SNP rs710886 may act as a potential biomarker for bladder cancer risk.

• 出版日期2017-9-5
• 单位南京医科大学