An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups

作者：Pinto Valerian B^*; Moran Elizabeth E; Cruz Francisco; Wang Xin Ming; Fridman Arthur; Zollinger Wendell D; Przysiecki Craig T; Burden Robert

来源：Vaccine, 2011, 29(44): 7752-7758.

DOI：10.1016/j.vaccine.2011.07.124

• Neisseria meningitidis
• Vaccine
• Outer membrane vesicles

A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y. W135, X. and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains. Published by Elsevier Ltd.

• 出版日期2011-10-13