An anthraquinone compound and its protective effects against homocysteine-induced cytotoxicity and oxidative stress

作者：Lin, Lixia; Du, Huizhi^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018, 202: 314-318.

DOI：10.1016/j.saa.2018.05.058

• 1,4-diactylateanthracene-9,10-dione
• Antioxidant activity
• Homocysteine
• Alzheimer's disease

In this work, we designed an anthraquinone derivative: 1,4-diacrylateanthracene-9,10-dione (DAAD) with antioxidant activity for preventing Alzheimer's disease (AD) through preventing the neurotoxicity of Homocysteine (Hcy). This compound has very low cytotoxicity and protects the cells against Hcy-induced cytotoxicity and oxidative stress. Thus, maybe DAAD can be used as a potential reagent to preventing AD. In addition, we investigated the UV-Vis and fluorescence spectra of DAAD in PBS (pH 7.29)/DMSO (v/v, 1:1) solution for detecting Hcy, and the detection limit of DAAD for Hcy was found to be 0.121 mu M. Thus, DAAD also can be used to monitor the Hcy level in plasma and cells.

• 出版日期2018-9-5
• 单位山西大学