Alleles and haplotypes of the interleukin 10 gene polymorphisms are associated with risk of developing acute coronary syndrome in Mexican patients

作者：Manuel Fragoso Jose; Vallejo Maite; Alvarez Leon Edith; Delgadillo Hilda; Antonio Pena Duque Marco; Cardoso Saldana Guillermo; Posadas Romero Carlos; Antonio Martinez Rios Marco; Vargas Alarcon Gilberto^*

来源：Cytokine, 2011, 55(1): 29-33.

DOI：10.1016/j.cyto.2011.03.021

• Acute coronary syndrome
• Genetic susceptibility
• Inflammation
• Interleukin 10
• Polymorphisms

Inflammation plays an important role in the pathogenesis of atherosclerosis and acute coronary syndromes (ACS). Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that mediates the inflammatory process. The objective of the present study was to evaluate the role of IL-10 gene polymorphisms as susceptibility markers for ACS in Mexican patients. IL-10 promoter polymorphisms (positions -1082, -819, and -592) were analyzed by 5' exonuclease TaqMan genotyping assays in 389 ACS patients and 302 healthy controls. ACS patients showed increased frequencies of IL-10-592 C allele and CC genotype when compared to healthy controls (pC = 0.0006, OR = 1.48 and pC = 0.022, OR = 1.56, respectively), whereas the frequencies of the A allele and AA genotype were decreased in patients (pC = 0.0006, OR = 0.68 and pC = 0.006, OR = 0.57, respectively). When the distribution of IL-10-592 genotypes was analyzed separately in women and men (patients and healthy controls), a different distribution of alleles and genotypes was observed only in the group of men. In this case, increased frequency of C allele (pC = 0.004, OR = 1.46) and decreased frequencies of A allele (pC = 0.004, OR = 0.68) and AA genotype (pC = 0.023, OR = 0.56) were observed in the group of patients when compared to healthy controls. Multiple logistic analyses by gender showed that male individuals with IL-10-592 CC + AC genotypes had 3.54-fold increased risk of developing ACS than individuals with AA genotype (p < 0.001). The analysis of linkage disequilibrium showed one (ACC) increased haplotype in patients as compared to healthy controls. The results suggest that IL-10 gene polymorphisms could be involved in the risk of developing ACS in the Mexican population.

• 出版日期2011-7