Madangones A and B: Two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities

作者：Salleh Wan Mohd Nuzul Hakimi Wan; Ahmad Farediah^*; Yen Khong Heng; Zulkifli Razauden Mohamed; Sarker Satyajit Dey

来源：Phytochemistry Letters, 2016, 15: 168-173.

DOI：10.1016/j.phytol.2016.01.004

• Beilschmiedia madang
• Neolignan
• Antioxidant
• Acetylcholinesterase
• Anti-inflammatory

Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, beta-sitosterol and beta-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 mu M. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 mu M, respectively.

• 出版日期2016-3