Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations

作者：Tang, Na; Li, Jia-Wei; Liu, Yong-Min; Zhong, Hua; Wang, La-Mei; Deng, Feng-Mei; Hui, Jing; Qu, Yuan-Yuan; He, Fang^*

来源：WIENER KLINISCHE WOCHENSCHRIFT, 2017, 129(19-20): 709-716.

DOI：10.1007/s00508-017-1239-2

• Human cytomegalovirus
• Blood pressure
• Risk factors
• Kazakh Chinese
• Han Chinese

Human cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations. @@@ Kazakh and Han (n = 800 each) (age,>= 18 years) subjects from Xinjiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples. @@@ Multivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women. @@@ The association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.

• 出版日期2017-10
• 单位石河子大学; 成都大学