A Multifunctional PB@mSiO(2)-PEG/DOX Nanoplatform for Combined Photothermal-Chemotherapy of Tumor

作者：Su, Yun Yan; Teng, Zhaogang; Yao, Hui; Wang, Shou Ju; Tian, Ying; Zhang, Yun Lei; Liu, Wen Fei; Tian, Wei; Zheng, Li Juan; Lu, Nan; Ni, Qian Qian; Su, Xiao Dan; Tang, Yu Xia; Sun, Jing; Liu, Ying; Wu, Jiang; Yang, Gui Fen^*; Lu, Guang Ming^*; Zhang, Long Jiang^*

来源：ACS Applied Materials & Interfaces, 2016, 8(27): 17038-17046.

DOI：10.1021/acsami.6b01147

• Prussian blue
• mesoporous silica
• photoacoustic tomography
• magnetic resonance imaging
• photothermo-chemotherapy

In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@ mSiO(2)-PEG nanocubes. The PB@mSiO(2)-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO(2)-PEG nanocubes, the constructured PB@mSiO(2)-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO(2)-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.

• 出版日期2016-7-13
• 单位南京邮电大学; 南京大学