Direct synthesis of pyrrolo[2,1-a]isoquinolines by 1,3-dipolar cycloaddition of stabilized isoquinolinium N-ylides with vinyl sulfonium salts

作者：An, Jing; Yang, Qing-Qing; Wang, Qiang; Xiao, Wen-Jing^*

来源：Tetrahedron Letters, 2013, 54(29): 3834-3837.

DOI：10.1016/j.tetlet.2013.05.053

• Pyrrolo[2,1-a]isoquinoline
• 1,3-Dipolar cycloaddition
• Isoquinolinium N-ylides
• Vinyl sulfonium salts

A direct and efficient synthesis of 2,3-unsubstituted 1-acylpyrrolo[2,1-a]isoquinolines is described. The 1,3-dipolar cycloaddition of stabilized isoquinolinium N-ylides with vinyl sulfonium salts features simple experimental procedures, mild conditions, and moderate to good yields.

• 出版日期2013-7-17
• 单位华中师范大学