Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

作者：Howells David W^*; Porritt Michelle J; Rewell Sarah S J; O'Collins Victoria; Sena Emily S; van der Worp H Bart; Traystman Richard J; Macleod Malcolm R

来源：Journal of Cerebral Blood Flow and Metabolism, 2010, 30(8): 1412-1431.

DOI：10.1038/jcbfm.2010.66

• animal models
• diabetes
• hypertension
• physiologic control
• stroke
• vascular variability

No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1412-1431; doi: 10.1038/jcbfm.2010.66; published online 19 May 2010

• 出版日期2010-8