Autoimmune manifestations in viral hepatitis

作者：Vergani Diego^*; Mieli Vergani Giorgina

来源：Seminars in Immunopathology, 2013, 35(1): 73-85.

DOI：10.1007/s00281-012-0328-6

• Hepatitis C
• Hepatitis B
• Hepatitis D
• Autoimmunity
• Immune complex disease
• Molecular mimicry
• Regulatory T cells
• B lymphocyte activation

Infections by the viruses responsible for hepatitis B, C and D are accompanied by a number of immunopathological manifestations. A link between infection and autoimmunity is particularly well documented for the hepatitis C virus. Immunopathological manifestations range from production of autoantibodies to overt autoimmune disease, including thyroiditis and autoimmune hepatitis, and to immune-complex-mediated disorders, including cryoglobulinaemia, glomerulonephritis and vasculitis. Several of these manifestations improve with successful antiviral treatment, directly incriminating the virus in their pathogenesis. Mechanisms considered responsible for hepatitis virus-related immunopathology, including molecular mimicry, impairment of regulatory T cells and activation of B lymphocytes, will be examined in this review.

• 出版日期2013-1