A game of musical chairs: Pro- and anti-resection factors compete for TOP BP1 binding after DNA damage

作者：Shimada Kenji^*; Gasser Susan M

来源：The Journal of Cell Biology, 2017, 216(3): 535-537.

DOI：10.1083/jcb.201701038

<jats:p>DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. <jats:italic>J. Cell Biol.</jats:italic><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1083/jcb.201607031" ext-link-type="uri">https://doi.org/10.1083/jcb.201607031</jats:ext-link>) report that the conserved scaffold protein TOPBP1<jats:sup>Dpb11</jats:sup> provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation.</jats:p>

• 出版日期2017-3