Understanding Biofilms in Chronic Sinusitis

作者：Tajudeen Bobby A^*; Schwartz Joseph S; Palmer James N

来源：Current Allergy and Asthma Reports, 2016, 16(2): 10.

DOI：10.1007/s11882-015-0591-4

• Biofilms
• Chronic sinusitis
• Bitter taste receptors
• T2R38
• Sinus surgery
• Innate immunity

Chronic sinusitis is a burdensome disease that has substantial individual and societal impact. Although great advances in medical and surgical therapies have been made, some patients continue to have recalcitrant infections. Microbial biofilms have been implicated as a cause of recalcitrant chronic sinusitis, and recent studies have tried to better understand the pathogenesis of chronic sinusitis as it relates to microbial biofilms. Here, we provide an overview of biofilms in chronic sinusitis with emphasis on pathogenesis, treatment, and future directions. In addition, recent evidence is presented, elucidating the role of bitter taste receptors as a possible key factor leading to biofilm formation.

• 出版日期2016-2