ASSESSMENT OF THE IN VITRO RELEASE OF ALENDRONATE SODIUM FROM MESOPOROUS SILICA PARTICLES

作者：Ochiuz Lacramioara; Luca Mihaela Catalina; Stoleriu Iulian; Moscalu Mihaela; Timofte Daniel; Tantaru Gladiola^*; Stefanache Alina

来源：Farmacia, 2016, 64(1): 131-134.

• alendronate
• mesoporous silica
• modified drug release

The objective of this study was to assess the influence of pore structure on the process of loading and releasing alendronate (AL) from modified release particles based on mesoporous silica. Two types of systems were prepared: AL@MCM41, using Mobile Composition of Matter no 41 (MCM 41) silica, with cylindrical pores arranged in a hexagonal structure, and AL@MCM48, based on Mobile Composition of Matter no 48 (MCM 48) silica with cubic structure and cylindrical radial pores diverging in three directions. After preparing the silicate matrices, AL was immobilized in the two mesoporous silica using the adsorption technique. For each type of silica particles we performed the in vitro dissolution test with simulating gastrointestinal fluids. Subsequently, the release profile of AL from the two types of mesoporous silica was obtained and the AL pharmacokinetics was analysed by fitting on mathematical models. The results obtained showed that pore structure of silicate materials have a key role in both loading capacity of silica with AL and rate of release of this drug substance.

• 出版日期2016-2