Phosphoinositide phosphatases in a network of signalling reactions

作者：Blero Daniel; Payrastre Bernard; Schurmans Stephane; Erneux Christophe^*

来源：Pflugers Archiv-European Journal of Physiology, 2007, 455(1): 31-44.

DOI：10.1007/s00424-007-0304-5

• poly-phosphoinositides
• inositol 1,4,5-trisphosphate
• PTEN
• inositol polyphosphate 5-phosphatases
• myotubularin
• SHIP phosphatases

Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P-2 4-phosphatase family, the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), SAC1 domain phosphatases and myotubularins belong to the tyrosine protein phosphatases superfamily. They share the presence of a conserved cysteine residue in the consensus CX5RT/S. Another family consists of the inositol polyphosphate 5-phosphatase isoenzymes. The importance of these phosphoinositide phosphatases in cell regulation is illustrated by multiple examples of their implications in human diseases such as Lowe syndrome, X-linked myotubular myopathy, cancer, diabetes or bacterial infection.

• 出版日期2007-10