Non-extracorporeal circulation for coronary artery bypass graft surgery is more beneficial than extracorporeal circulation

作者：Yang F Y; Bao Y Z; Liu F S; Zhu Y C; Zheng J; Zhang J H; Zheng X F; Wei G C^*

来源：European Review for Medical and Pharmacological Sciences, 2015, 19(8): 1452-1456.

• Pulmonary infection
• Inflammation
• markers
• Non-extracorporeal circulation
• Extracorporeal circulation
• Coronary artery bypass grafting

OBJECTIVE: The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study outcomes included operative time, number of graft vessels, pulmonary infection rates, and systemic inflammatory markers.
PATIENTS AND METHODS: 96 patients received selective CABG, either with non-extracorporeal (study group; n = 48) or extracorporeal circulation (control group; n = 48). Operative time, pulmonary infection rates, and blood levels of inflammatory markers TNF-alpha, IL-6, and IL-8 before and 4, 24, and 48 hours after the surgery were quantified. Graft vessels were quantified using computed tomography.
RESULTS: Operative time was significantly shorter in study group (4.58 +/- 0.91 vs. 5.36 +/- 1.12 hours in control group; p < 0.05). The number of graft vessels and pulmonary infection rates were comparable between both techniques. However, systemic inflammatory markers were significantly (p < 0.05) lower in study group at 4 and, partly, 24 hours after the surgery.
CONCLUSIONS: Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes.

• 出版日期2015-4
• 单位中国人民解放军第二军医大学; 青岛大学