Aberrant microRNA expression and its implications in the pathogenesis of leukemias

作者：Babashah Sadegh^*; Sadeghizadeh Majid; Tavirani Mostafa Rezaei; Farivar Shirin; Soleimani Masoud

来源：Cellular Oncology, 2012, 35(5): 317-334.

DOI：10.1007/s13402-012-0095-3

• MicroRNA
• Expression signature
• Acute myeloid leukemia
• Acute lymphoblastic leukemia
• Chronic myeloid leukemia
• Chronic lymphocytic leukemia

MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias. %26lt;br%26gt;Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL). %26lt;br%26gt;The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.

• 出版日期2012-10