Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence

作者：Liu Jianghong; Zhao Sophie R; Reyes Teresa

来源：International Journal of Molecular Sciences, 2015, 16(8): 18129-18148.

DOI：10.3390/ijms160818129

• molecular epigenetics
• nutrients
• brain dysfunction
• gene-environment interactions
• behavior problems
• psychopathology
• neurotoxicity

In recent years, a role for epigenetic modifications in the pathophysiology of disease has received significant attention. Many studies are now beginning to explore the gene-environment interactions, which may mediate early-life exposure to risk factors, such as nutritional deficiencies and later development of behavioral problems in children and adults. In this paper, we review the current literature on the role of epigenetics in the development of psychopathology, with a specific focus on the potential for epigenetic modifications to link nutrition and brain development. We propose a conceptual framework whereby epigenetic modifications (e.g., DNA methylation) mediate the link between micro- and macro-nutrient deficiency early in life and brain dyse.g., structural aberration, neurotransmitter perturbation), which has been linked to development of behavior problems later on in life.

• 出版日期2015-8