An insight into the role of arachidonic acid derived lipid mediators in virus associated pathogenesis and malignancies

作者：Chandrasekharan Jayashree A; Marginean Alexandru; Sharma Walia Neelam^*

来源：Prostaglandins & Other Lipid Mediators, 2016, 126: 46-54.

DOI：10.1016/j.prostaglandins.2016.07.009

• Lipid mediators
• Arachidonic acid
• Kaposi's sarcoma associated herpes virus
• Cyclooxygenase
• Prostaglandins
• Leukotriene
• Lipoxins
• Resolvins

Several studies shed light on the size and diversity of the lipidome, along with its role in physiological and pathological processes in human health. Besides that, lipids also function as important signaling mediators. This review focuses on discussing the role of arachidonic acid (AA) derived lipids as mediators in diseases with special emphasis on viral infections. Structurally, arachidonic acid derived lipids, also referred to as lipid mediators, can be classified into three specific classes: Class 1-eicosanoids derived from arachidonic acid metabolism; Class 2-lysophospholipids consisting of either a glycerol or a sphingosine backbone; Class 3-AA and (omega-3 polyunsaturated fatty acid (PUPA) derivatives. Class 1 and 2 lipids are commonly referred to as pro-inflammatory molecules, which are found upregulated in diseases like cancer and viral infection. Class 3 lipids are anti-inflammatory molecules, which could be potentially used in treatment of diseases associated with inflammation. The function of each class has been elucidated as unique and contributory to an overall cellular homeostasis. Current work in this field is promising and will surely usher in a new era of lipid understanding and control not only at the molecular level, but also in terms of holistic patient care.

• 出版日期2016-11