Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk

作者：Zhou, Shengjun; Zhao, Jikuang; Wang, Zhepei; Li, Keqin; Nie, Sheng; Gao, Feng; Sun, Jie; Gao, Xiang^*; Huang, Yi

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(12): 22503-22508.

• Hemorrhagic stroke
• BUD13-ZNF259
• SNP
• rs964184
• TG

We aimed to evaluate the association of rs964184 of BUD13-ZNF259 gene with the risk of hemorrhagic stroke (HS). A total of 138 HS cases and 587 controls were recruited for the association of rs964184 of BUD13-ZNF259 gene with the risk of HS. Tm shift PCR was used for genotyping. We were unable to find the association of rs964184 of BUD13-ZNF259 gene with the risk of HS (P>0.05). Significant difference was found in the TG level among the three genotypes (CC: 1.51 +/- 1.02; CG: 1.68 +/- 1.10; GG: 1.90 +/- 1.11, P=0.036). The TG level showed strong correlation with rs964184 genotypes (P=0.010, correlation=0.101). Significantly higher TC, HDL-C, and LDL-C levels were observed in the case group. And no difference was found in the TG, ApoA-I, ApoB. Our case-control study supported the significant association between rs964184 genotype and the blood TG concentration, although we were unable to find association between BUD13-ZNF259 rs964184 and the risk of HS in Han Chinese.

• 出版日期2015
• 单位浙江大学