Toll-Like Receptor 2 Gene Polymorphisms in a Korean Population: Association With Chronic Rhinosinusitis

作者：Park Chan Soon; Cho Jin Hee; Park Yong Jin^*

来源：Otolaryngology - Head and Neck Surgery, 2011, 144(1): 96-100.

DOI：10.1177/0194599810390881

• toll-like receptor
• polymorphism
• single-nucleotide polymorphism
• sinusitis

Objective. To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls.
Study Design and Setting. A case-control study.
Subjects and Methods. Subjects (N = 214) were all adults (> 20 years old) and were divided into patients with CRS (n = 106) and controls (n = 108). Five SNPs (rs1898830, rs3804099, rs3804100, R677W, and rs5743708) were selected and genotyped in a case-control study with the single-base-pair primer extension (SNaPshot) assay.
Results. The case-control study revealed that 2 SNPs in TLR2, rs3804099 (odds ratio [OR] = 2.88; 95% confidence interval [CI] = 1.17-7.09; P =.022) and rs3804100 (OR = 3.76; 95% CI = 1.42-9.96; P =.008), showed significant differences in minor allele frequency between CRS patients and controls. These 2 SNPs were correlated with CRS risk in Korean patients.
Conclusions. Two SNPs in TLR2 may be associated with increased risk of CRS in Korean subjects.

• 出版日期2011-1