A Systems Biology Approach to Personalizing Therapeutic Combinations

作者:Kwong Lawrence N*; Heffernan Timothy P; Chin Lynda
来源:Cancer Discovery, 2013, 3(12): 1339-1344.
DOI:10.1158/2159-8290.CD-13-0394

摘要

The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.

  • 出版日期2013-12