Dinuclear cadmium indomethacin and Lawsone complexes: synthesis, crystal structures, antiproliferative and biological evaluations

作者：Tabrizi Leila; Golbang Reza; Sadeghi Hamid; Chiniforoshan Hossein; Mcardle Patrick; Notash Behrouz

来源：Journal of Coordination Chemistry, 2016, 69(20): 3021-3034.

DOI：10.1080/00958972.2016.1223845

• Cadmium(II) complex
• indomethacin
• Lawsone
• DNA binding
• BSA binding
• cytotoxicity

The synthesis and structural characterizations of Cd(II) indomethacin (Indo) and Lawsone (Law) complexes, K-2[Cd-2(Indo)(4)(SCN)(2)], 1 and [Cd-2(Law)(4)(phen)(2)]4CH(3)OH, 2 (SCN=thiocyanate, phen=1,10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) and X-ray crystallography. The interaction of indomethacin and Lawsone ligands, 1 and 2 with calf thymus DNA and bovine serum albumin were investigated using UV-visible and fluorescence spectrophotometric methods. The in vitro cytotoxicity of 1 and 2 was examined against promyelocytic leukemia (HL-60), colon (HCT-8), brain (SF-295), and melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria were tested.
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• 出版日期2016