Application of rapidly generated bidentate ligand libraries to zinc catalyzed reductions

作者：Zaman Tariq; Frauenlob Robin; McCarthy Robert; Walsh Carolyn M; Bergin Enda^*

来源：Journal of Organometallic Chemistry, 2012, 716: 159-166.

DOI：10.1016/j.jorganchem.2012.06.013

• Combinatorial catalysis
• Asymmetric catalysis
• Hydrosilylation
• Ligand libraries

A methodology for the combinatorial synthesis of bidentate ligands - allowing direct screening of reaction products without the need for isolation or purification - has been employed in a zinc catalyzed hydrosilylation. This reaction allowed the robustness of the methodology to be examined, by employing it in a challenging case where the metal complex is not pre-formed prior to catalysis. Four different ligand families have been examined: imines, aminals, bis-imines and oxazolines and related compounds, with a small library of each type produced and directly screened in the reaction. Three ligands providing enantioselectivities of 50% or more in this very challenging reaction were identified, and ees and conversions were equivalent whether the ligand was obtained as a crude mixture from a library synthesis or as an isolated, purified compound.

• 出版日期2012-10-1