A molecular risk score integrating BAALC, ERG and WT1 expression levels for risk stratification in acute promyelocytic leukemia

作者：Hecht Anna^*; Nowak Daniel; Nowak Verena; Hanfstein Benjamin; Buechner Thomas; Spiekermann Karsten; Weiss Christel; Hofmann Wolf Karsten; Lengfelder Eva; Nolte Florian

来源：Leukemia Research, 2015, 39(11): 1172-1177.

DOI：10.1016/j.leukres.2015.08.010

• Acute promyelocytic leukemia
• Molecular risk factors
• Prognosis
• Relapse
• Survival

To date risk stratification in acute promyelocytic leukemia (APL) is based on highly dynamic leukocyte and platelet counts only. To identify a more robust risk stratification model, a molecular risk score was developed based on expression levels of the genes BAALC, ERG and WTI. Hereby, the main focus was on prediction of relapse. The integrative risk score divided patients into two groups with highly significant differences in outcome. It discriminated a high risk group with a high incidence of relapse successfully from a low risk group with no APL-related events after achievement of first remission. Especially the concurrent presence of molecular risk factors showed to be a negative prognostic factor in APL. The molecular risk score might be a promising approach to guide monitoring of APL patients and therapeutic decisions in the future.

• 出版日期2015-11