Alzheimer%26apos;s and prion diseases: PDK1 at the crossroads

作者：Checler Frederic^*

来源：Nature Medicine, 2013, 19(9): 1088-1090.

TACE-mediated proteolysis is a key event interfering with both Alzheimer%26apos;s and prion diseases. A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer%26apos;s and prion pathologies (pages 1124-1131).

• 出版日期2013-9