The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions

作者：Amartely Hadar; David Ahuvit; Lebendiker Mario; Benyamini Hadar; Izraeli Shai; Friedler Assaf^*

来源：Chemical Communications, 2014, 50(40): 5245-5247.

DOI：10.1039/c3cc45096a

The STIL protein participates in mitosis and malignant transformation by regulating centrosomal duplication. Using biophysical methods we studied the structure and interactions of STIL. We revealed that its central domain is intrinsically disordered and mediates protein-protein interactions of STIL. The intrinsic disorder may provide STIL with the conformational flexibility required for its multitude binding.

• 出版日期2014