Facile Synthesis of a Library of Lyme Disease Glycolipid Antigens

作者：Twibanire Jean d' Amour K; Omran Raha Parvizi; Grindley T Bruce^*

来源：Organic Letters, 2012, 14(15): 3909-3911.

DOI：10.1021/ol301697c

A library of one of the two Lyme disease antigens, BbGL1, has been synthesized in four steps from D-galactose using BF3-promoted glycosylation of the peracetate to introduce the cholesteryl beta-glycoside and TBTU-promoted esterification to add a range of fatty acids regioselectively at O-6 of D-galactose in good yield.

• 出版日期2012-8-3