Embedded Plasmonic Nanomenhirs as Location-Specific Biosensors

作者：Kumar Karthik^*; Dahlin Andreas B; Sannomiya Takumi; Kaufmann Stefan; Isa Lucio; Reimhult Erik

来源：Nano Letters, 2013, 13(12): 6122-6129.

DOI：10.1021/nl403445f

• Biosensing
• nanoplasmonics
• asymmetric nanostructures
• location specificity
• nanopatterning
• liposome
• supported lipid bilayers
• evanescent

We introduce a novel optical biosensing platform that exploits the asymmetry of nanostructures embedded in nanocavities, termed nanomenhirs. Upon oblique illumination using plane polarized white light, two plasmonic resonances attributable to the bases and the axes of the nanomenhirs emerge; these are used for location-specific sensing of membrane-binding events. Numerical simulations of the near field distributions confirmed the experimental results. As a proof-of-concept, we present a model biosensing experiment that exploits the dual-sensing capability, the size selectivity offered by the sensor geometry, and the possibility to separately biochemically modify the nanomenhirs and the nanocavities for the specific binding of lipid membrane structures to the nanomenhirs.

• 出版日期2013-12