Antimicrobial Properties of Substituted Quino [3,2-b]benzo[1,4] thiazines

作者：Czarny Anna; Zaczynska Ewa; Jelen Malgorzata; Zimecki Michal^*; Pluta Krystian; Morak Mlodawska Beata; Artym Jolanta; Kocieba Maja

来源：Polish Journal of Microbiology, 2014, 63(3): 335-339.

DOI：10.33073/pjm-2014-044

• phenothiazines
• azaphenothiazines
• antibacterial activity
• antifungal activity
• structure-activity relationship

Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF alpha) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl-2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.

• 出版日期2014