Gas-mediated vitreomacular adhesion release with intravitral ranibizumab injections for exudative age-related macular degeneration

作者：Kang Hae Min; Lee Sung Jun; Kim Chul Gu; Chung Eun Jee; Koh Hyoung Jun^*

来源：Graefes Archive for Clinical and Experimental Ophthalmology, 2016, 254(9): 1681-1692.

DOI：10.1007/s00417-015-3257-y

• lAge-related macular degeneration
• Perfluoropropane
• Posterior vitreous detachment
• Vitreomacular adhesion
• Vitreomacular traction

To evaluate the efficiency of gas-assisted vitreomacular adhesion (VMA) release combined with intravitreal ranibizumab injections for exudative age-related macular degeneration (AMD) patients.
This prospective, interventional case series included a total of 23 eyes of 22 patients. The eyes were treated with intravitreal injection of 0.3 mL of perfluoropropane (C3F8) gas and concomitant intravitreal ranibizumab injection to stimulate VMA release. After three initial loading injections, additional intravitreal ranibizumab injections were performed pro re nata. Over a 12-month period, monthly examinations were performed for best-corrected visual acuity (BCVA, logMAR; logarithm of the minimum angle resolution), optical coherence tomography, and dilated fundus examinations.
After gas injection, 22 eyes (95.7 %) showed complete VMA release at 1 week. Complete VMA was achieved in all eyes at 2 months after VMA release, without serious ocular adverse events except one patient who developed a retinal tear. Mean BCVA was 0.61 +/- 0.37 logMAR (20/81 Snellen equivalents) at baseline and 0.46 +/- 0.30 logMAR (20/57 Snellen equivalents) at 12 months (P = 0.135). Mean central macular thickness was 357.9 +/- 128.6 mu m at baseline and 245.6 +/- 60.0 mu m at 12 months (P = 0.188). Mean numbers of intravitreal ranibizumab injections were 4.8 +/- 2.4 times during 12 months (4 to 8 injections).
Gas-assisted VMA release can be used as an efficient alternative for exudative AMD patients with obvious VMA.

• 出版日期2016-9