Anticholinergic medication use is associated with globus pharyngeus

作者：Haft S; Carey R M^*; Farquhar D; Mirza N

来源：Journal of Laryngology and Otology, 2016, 130(12): 1125-1129.

DOI：10.1017/S002221511600918X

• Anticholinergics
• Globus
• Drug Side Effects
• Reflux Symptom Index
• Sicca
• Laryngopharyngeal Reflux

Background: Globus pharyngeus has been linked to salivary hypofunction. We hypothesise that a considerable portion of the globus experienced by patients is due to a drying effect secondary to anticholinergic medication use; this study aimed to determine their association.
Methods: A cross-sectional study was conducted of 270 patients who presented to a laryngology practice over 6 months. Participants rated globus sensation on a 5-point severity scale, with those scoring 0 considered as controls (non-globus). Participants were excluded if they had a likely cause of globus. Scores were compared with participants' medication lists, co-morbidities, age and gender, and evaluated using multivariate analysis, with significance set at p < 0.05.
Results: Any participant taking at least 2 anticholinergic medications had a 3.52 increased odds (p = 0.02) of experiencing globus. A previous diagnosis of gastroesophageal reflux disease was also significantly associated with globus (p = 0.004), with an odds ratio of 3.75.
Conclusion: A substantial portion of idiopathic globus may be due to anticholinergic use or reflux. The findings implicate medication use as a risk factor for globus. An awareness of these associations is invaluable for identifying cause and treating globus.

• 出版日期2016-12