A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of beta,beta-Disubstituted Nitroalkenes

作者：Zhao, Qingyang; Li, Shengkun; Huang, Kexuan; Wang, Rui^*; Zhang, Xumu

来源：Organic Letters, 2013, 15(15): 4014-4017.

DOI：10.1021/ol401816y

• TRANSITION-METAL-COMPLEXES
• ENANTIOSELECTIVE CONJUGATE REDUCTION
• SYNERGISTIC CATALYSIS
• ORGANIC-SYNTHESIS
• BRONSTED ACID
• HYDROFORMYLATION
• ALKENES
• BIOREDUCTION
• ALDEHYDES
• KETONES

A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly enantioselective hydrogenation of beta,beta-disubstituted nitroalkenes (up to 99% yield and 99% ee). With low catalytic loading (0.25 mol %), 98% ee and 98% conversion were obtained. The thiourea group takes on an important role in this catalytic system.

• 出版日期2013-8-2
• 单位兰州大学; rutgers