Association between ABCA1 gene polymorphisms and the therapeutic response to donepezil therapy in Han Chinese patients with Alzheimer's disease

作者：Lu, Jin; Fu, Jianliang; Zhong, Yuan; Yang, Quanjun; Huang, Jinlu; Li, Jie; Huo, Yan; Zhao, Yuwu; Wan, Lili^*; Guo, Cheng^*

来源：Brain Research Bulletin, 2018, 140: 1-4.

DOI：10.1016/j.brainresbull.2018.03.014

• STEREOSELECTIVE METABOLISM
• CHOLESTEROL HOMEOSTASIS
• PLASMA-CONCENTRATION
• CYP2D6
• RISK
• APOE
• DEFICIENCY
• SECRETION
• VARIANTS
• DEMENTIA

Aim: It is reported that ABCA1, which plays a key role in cholesterol transport and apolipoprotein E (APOE) metabolism in the brain, is related to Alzheimer's disease. However, few studies have focused on the relationship between the ABCA1 gene and the therapeutic response to donepezil (DNP), which has been shown to be related to reduced sAPP production. This study evaluated the association between the ABCAJ gene polymorphism and the clinical response to donepezil therapy in Han Chinese patients with Alzheimer's disease. @@@ Methods: We examined ABCA1 gene polymorphisms in 88 Han Chinese patients with Alzheimer's disease who were receiving DNP therapy. The Mini-Mental State Examination was conducted before and after DNP treatment, and the ABCAI rs 2230806 and rs 2230808, APOE E3 genotypes of each patient were identified. @@@ Results: We found that patients with the ABCA1 rs2230806 GG genotype responded better to DNP treatment compared to those with the AA and AG genotypes (p = 0.001). Patients who were APOE E3 non-carriers and had the ABCA1 rs2230806 GG genotype tended to have a better clinical response to DNP therapy. @@@ Conclusions: The ABCAJ rs 2230806 polymorphism and its combination with the APOE E3 allele may provide clinically relevant information for predicting the therapeutic response to DNP therapy.

• 出版日期2018-6
• 单位上海交通大学