Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

作者：Tomitaka Asahi; Arami Hamed; Raymond Andrea; Yndart Adriana; Kaushik Ajeet; Jayant Rahul Dev; Takemura Yasushi; Cai Yong; Toborek Michal; Nair Madhavan^*

来源：Nanoscale, 2017, 9(2): 764-773.

DOI：10.1039/c6nr07520gD

Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

• 出版日期2017