科研之友
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摘要
The efficacy of acupuncture in smoking cessation, and its effect on the urge to smoke are unclear. We evaluated the effect of a standardized protocol of transcutaneous electric acupoint stimulations (TEAS) on alleviating the urge to smoke. Ninety-eight smokers were recruited in two double-blind studies. Participants abstained from smoking for 26 h, and were randomized to receive TEAS alternating between 2 and 100Hz at four acupoints (LI4 and PC8, PC6 and TE5) at four different intensities (10, 5, Intermittent 5 or 0 mA). The urge to smoke was assessed by the Questionnaire of Smoking Urges (QSU-Brief). In Experiment 1, the 10mA group (n = 20) was compared with the 5mA group (n = 20); the increase in smoking urges did not differ significantly. Considering the possibility that 5mA may be an active intervention, in Experiment 2, a true placebo (0mA), and a proxy of placebo [ Intermittent 5mA (i5mA)] were compared with 10 mA TEAS. In this experiment, 10mA (n = 20) TEAS showed a tendency to alleviate smoking urges compared with 0mA (n = 16), and i5 mA (n = 19) TEAS. Only when the data of smokers with Fagerstom Test for Nicotine Dependence score >= 5 were analyzed that the difference between the 10mA group and the control group (0 and i5 mA) became significant. Based on these preliminary findings, we conclude that TEAS applied on the skin may antagonize the increase in urge to smoke in abstinent-dependent smokers. It seems warranted to assess the efficacy of TEAS in smoking cessation clinical trials involving a larger population of dependent smokers.
- 出版日期2011
- 单位北京大学
