ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

作者：Heyman, Jefri; Cools, Toon; Vandenbussche, Filip; Heyndrickx, Ken S.; Van Leene, Jelle; Vercauteren, Ilse; Vanderauwera, Sandy; Vandepoele, Klaas; De Jaeger, Geert; Van Der Straeten, Dominique; De Veylder, Lieven^*

来源：Science, 2013, 342(6160): 860-863.

DOI：10.1126/science.1240667

• ARABIDOPSIS-THALIANA
• PHYTOSULFOKINE
• MERISTEM
• GROWTH
• PROLIFERATION
• MAINTENANCE
• COMPLEX
• FATE

The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C-CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.

• 出版日期2013-11-15