New Rugulosins, Anti-MRSA Antibiotics, Produced by Penicillium radicum FKI-3765-2

作者:Yamazaki Hiroyuki; Koyama Nobuhiro; Omura Satoshi; Tomoda Hiroshi*
来源:Organic Letters, 2010, 12(7): 1572-1575.
DOI:10.1021/ol100298h

摘要

New rugulosins B (2) and C (3) were isolated together with known rugulosin (renamed rugulosin A In this paper, 1) from whole culture of Penicillium radicum FKI-3765-2, and their structures were elucidated by NMR spectroscopy. Rugulosins A and C were a homodimer of the same anthraquinone moieties, whereas rugulosin B was a heterodimer of analogous anthraquinone moieties. Rugulosins A to C showed antimicrobial activity against methicillin-resistant Staphylococcus aureus.

  • 出版日期2010-4-2