An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients

作者：Enomoto Hirayuki^*; Aizawa Nobuhiro; Nakamura Hideji; Sakai Yoshiyuki; Iwata Yoshinori; Tanaka Hironori; Ikeda Naoto; Aoki Tomoko; Yuri Yukihisa; Yoh Kazunori; Hashimoto Kenji; Ishii Akio; Takashima Tomoyuki; Iwata Kazunari; Saito Masaki; Imanishi Hiroyasu; Iijima Hiroko; Nishiguchi Shuhei

来源：Gastroenterology Research and Practice, 2014, 2014: 351396.

DOI：10.1155/2014/351396

Background. In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated. Methods. A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis. Results. The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 +/- 0.24, F2: 2.65 +/- 0.24, F3: 2.74 +/- 0.38, and F4: 2.91 +/- 0.63). The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage (P < 0.0001), platelet count (P < 0.0001), albumin value (P < 0.0001), and cholinesterase value (P < 0.0001). The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 (P < 0.0001) and the AST-to-platelet ratio index (APRI) (P < 0.0001). Furthermore, the GA/HbA1c showed better correlations with two variables of liver PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI. Conclusion. The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients.

• 出版日期2014