An assay that may predict the development of IgG enhancing allergen-specific IgE binding during birch immunotherapy

作者：Selb R; Eckl Dorna J; Vrtala S; Valenta R^*; Niederberger V

来源：Allergy, 2013, 68(9): 1199-1202.

DOI：10.1111/all.12204

• Bet v 1
• birch pollen allergy
• enhancing IgG antibodies
• immunotherapy
• recombinant allergen

BackgroundIt has been shown that birch pollen immunotherapy can induce IgG antibodies which enhance IgE binding to Bet v 1. We aimed to develop a serological assay to predict the development of antibodies which enhance IgE binding to Bet v 1 during immunotherapy. %26lt;br%26gt;MethodsIn 18 patients treated by Bet v 1-fragment-specific immunotherapy, the effects of IgG antibodies specific for the fragments on the binding of IgE antibodies to Bet v 1 were measured by ELISA. Blocking and possible enhancing effects on IgE binding were compared with skin sensitivity to Bet v 1 after treatment. %26lt;br%26gt;ResultsWe found that fragment-specific IgG enhanced IgE binding to Bet v 1 in two patients who also showed an increase of skin sensitivity to Bet v 1. %26lt;br%26gt;ConclusionOur results indicate that it may be possible to develop serological tests which predict the induction of unfavourable IgG antibodies enhancing the binding of IgE to Bet v 1 during immunotherapy.

• 出版日期2013-9