A cyclic peptide mimic of an RNA recognition motif of human La protein is a potent inhibitor of hepatitis C virus

作者：Manna Asit Kumar; Kumar Anuj; Ray Upasana; Das Saumitra; Basu Gautam; Roy Siddhartha^*

来源：Antiviral Research, 2013, 97(3): 223-226.

DOI：10.1016/j.antiviral.2012.12.026

• Cyclic peptide
• HCV tranlation
• Replicon
• Beta-turn

Due to limited available therapeutic options, developing new lead compounds against hepatitis C virus is an urgent need. Human La protein stimulates hepatitis C virus translation through interaction with the hepatitis C viral RNA. A cyclic peptide mimicking the beta-turn of the human La protein that interacts with the viral RNA was synthesized. It inhibits hepatitis C viral RNA translation significantly better than the corresponding linear peptide at longer post-treatment times. The cyclic peptide also inhibited replication as measured by replicon RNA levels using real time RT-PCR. The cyclic peptide emerges as a promising lead compound against hepatitis C.

• 出版日期2013-3