New pyrazoline derivatives and their antidepressant activity

作者：Kaplancikli Zafer Asim^*; Ozdemir Ahmet; Turan Zitouni Gulhan; Altintop Mehlika Dilek; Can Ozgur Devrim

来源：European Journal of Medicinal Chemistry, 2010, 45(9): 4383-4387.

DOI：10.1016/j.ejmech.2010.06.011

• Triazole
• Pyrazoline
• Antidepressant activity
• Modified forced swimming test
• Tail suspension tests
• Rota-Rod

Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities.

• 出版日期2010-9