Adiponectin modulates NK-cell function

作者：Wilk Sabrina; Jenke Alexander; Stehr Jenny; Yang Chin An; Bauer Sandra; Goeldner Katrin; Kotsch Katja; Volk Hans Dieter; Poller Wolfgang; Schultheiss Heinz Peter; Skurk Carsten; Scheibenbogen Carmen^*

来源：European Journal of Immunology, 2013, 43(4): 1024-1033.

DOI：10.1002/eji.201242382

• Adiponectin
• Adiponectin KO mice
• Adiponectin receptors 1 or 2
• Immunomodulation
• NK cells

Adiponectin (APN) has been shown to exert antiinflammatory effects in various disease models but little is known concerning its regulation of NK-cell function. Here, we show that the majority of human CD56dim NK cells express surface Adiponectin receptor (AdipoR) 1 and 2 while most CD56high NK cells are AdipoR-negative. Toll-like receptor (TLR) ligand-induced IFN- production was diminished by APN while it had no influence on NK-cell cytotoxicity. In contrast only a small subpopulation of murine NK cells expresses surface AdipoRs, but about 90% store them intracellularly. APN-deficient knockout (KO) mice had elevated frequencies of NK cells. However, cytotoxic degranulation of NK cells was decreased in APN knockout (APN-KO) animals. Accordingly, frequencies of CD11bhighCD27high and CD94high effector NK cells and expression of NKG2D were lower in APN-KO mice. Upon CVB3 infection NK-cell function was restored in APN-KO mice. Our data suggest that in addition to its antiinflammatory effects APN also influences the numerical and differentiation status of NK cells, which may further impact the outcome of immune-mediated diseases in APN-KO mice.

• 出版日期2013-4
• 单位河北医科大学