2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents

作者：Azizmohammadi Mohammad; Khoobi Mehdi; Ramazani Ali; Emami Saeed; Zarrin Abdolhossein; Firuzi Omidreza; Miri Ramin; Shafiee Abbas^*

来源：European Journal of Medicinal Chemistry, 2013, 59: 15-22.

DOI：10.1016/j.ejmech.2012.10.044

• Anti-cancer agents
• Cytotoxicity
• 2H-chromene
• Thiazolidine-2,4-dione
• Rhodanine
• Hydantoin

A variety of (Z)-[(2H-chromen-3-yl)methylene]azolidinones 6a-t bearing thiazolidine-2,4-dione, rhodanine or hydantoin scaffolds were designed and synthesized as potential anticancer agents. Inhibitory effect of synthesized compounds 6a-t on the viability of cancer and non-cancer cells was assessed using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction assay. The SAR study revealed that the N-substitution of azolidinone moiety cannot improve the activity but S/NH replacement (thiazolidine-2,4-dione/hydantoin) and S/O alteration (rhodanine/thiazolidine-2,4-dione) enable us to modulate the growth inhibition activity against various cell lines. Moreover, 6-bromo and 2-methyl substituents on chromene ring had positive effects on growth inhibitory activity depending on the tumor cell lines. Among the synthesized compounds, hydantoin derivative 60 with a 6-bromo-2-methyl-2H-chromene substructure showed the best profile of cytotoxicity comparable to that of cisplatin as standard anticancer agent.

• 出版日期2013-1