A case report of tongue metastasis from lung squamous cell carcinoma and literature review

作者：Cheng Xiaolong; Hu Zhenli; Han Yi-ping^*; Bai Chong

来源：Medicine, 2017, 96(40): UNSP e8208.

DOI：10.1097/MD.0000000000008208

• gene mutation
• literature review
• lung squamous cell carcinoma
• poor prognose
• tongue metastasis

Rationale: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor.
Patient concers: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis.
Diagnoses: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue.
Intervations: We send the biopsy of the lung and the tongue lesions for gene sequencing.
Outcomes: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later.
Lessons: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.

• 出版日期2017-10
• 单位中国人民解放军第二军医大学