A ruthenium(II) complex inhibits tumor growth in vivo with fewer side-effects compared with cisplatin

作者：Wang, Jin-Quan; Zhang, Ping-Yu; Ji, Liang-Nian; Chao, Hui^*

来源：Journal of Inorganic Biochemistry, 2015, 146: 89-96.

DOI：10.1016/j.jinorgbio.2015.02.003

• Ruthenium(II) complex
• Antitumor
• Mice
• Toxicity
• Cisplatin

The antitumor activity of a ruthenium(II) polypyridyl complex, Delta-[Ru(bpy)(2)(HPIP)](ClO4)(2) (Delta-Ru1, where bpy = 2,2'-bipyridine, HPIP = 2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline), was evaluated. The in vivo experiments showed that Delta-Ru1 inhibited the growth of a human cervical carcinoma cell line (HeLa) xenotransplanted into nude mice with efficiency similar to that of cisplatin. Histopathology examination of the tumors from treated xenograft models was consistent with apoptosis in tumor cells. Importantly, in striking contrast with cisplatin, Delta-Ru1 did not cause any detectable side effects on the kidney, liver, peripheral neuronal system, or the hematological system at the pharmacologically effective dose. The preclinical studies reported here provide support for the clinical use of Delta-Ru1 as an exciting new drug candidate with lower toxicity than cisplatin, endowed with proapoptotic properties.

• 出版日期2015-5
• 单位广东药科大学; 中山大学