Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes

作者：Foncea R; Galvez A; Perez V; Morales MP; Calixto A; Melendez J; Gonzalez Jara F; Diaz Araya G; Sapag Hagar M; Sugden PH; LeRoith D; Lavandero S^*

来源：Biochemical and Biophysical Research Communications, 2000, 273(2): 736-744.

DOI：10.1006/bbrc.2000.3008

• insulin-like growth factor-1
• protein kinases
• signal transduction
• apoptosis
• cardiac myocytes

This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide turnover, translocation of protein kinase C (PKC) isoforms (alpha, epsilon, and delta) from the soluble to the particulate fraction, activation of phospholipid-dependent and Ca2+-, phospholipid-dependent PKC, and activation of the extracellular-regulated kinase (ERK), IGF-1 attenuated sorbitol-induced cardiomyocyte viability and nuclear DNA fragmentation, These antiapoptotic effects of IGF-1 were blocked by PD098059 (an MEK inhibitor) but not by bisindolylmaleimide

• 出版日期2000-7-5