A Direct C2-Selective Phenoxylation and Alkoxylation of Quinoline N-Oxides with Various Phenols and Alcohols in the Presence of H-Phosphonate

作者：Bi, Wen-Zhu; Qu, Chen; Chen, Xiao-Lan^*; Qu, Ling-Bo^*; Liu, Zhi-Dong; Sun, Kai; Li, Xu; Zhao, Yu-Fen^*

来源：European Journal of Organic Chemistry, 2017, 2017(34): 5125-5130.

DOI：10.1002/ejoc.201701080

• Cross-coupling
• Quinolines
• Heterocycles
• Regioselectivity

A practical and efficient method for the synthesis of 2-aroxy(alkoxy)quinolines has been developed by direct cross-dehydrogenative coupling reaction between quinoline N-oxides and readily available phenols and alcohols in the presence of H-phosphonate and CCl4 under mild conditions.

• 出版日期2017-9-15
• 单位厦门大学; 郑州大学; 洛阳理工学院