Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark

作者：Chavan M J; Wakte P S; Shinde D B^*

来源：Phytomedicine, 2010, 17(2): 149-151.

DOI：10.1016/j.phymed.2009.05.016

• Annona squamosa
• Unsaponified petroleum ether extract
• Caryophyllene oxide
• Analgesic
• Anti-inflammatory

Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25 mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50 mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.

• 出版日期2010-2