Antibacterial activity of alkaloids produced by endophytic fungus Aspergillus sp EJC08 isolated from medical plant Bauhinia guianensis

作者：Pinheiro Eduardo Antonio A; Carvalho Josiwander Miranda; dos Santos Diellem Cristina P; Feitosa Andre de Oliveira; Marinho Patricia Santana B; Skelding Pinheiro Guilhon Giselle Maria; de Souza Afonso Duarte L; da Silva Felipe Moura A; Marinho Andrey Moacir do R^*

来源：Natural Product Research, 2013, 27(18): 1633-1638.

DOI：10.1080/14786419.2012.750316

• Bauhinia guianensis
• endophytic fungi
• alkaloids
• antibacterial assay
• Aspergillus

Bauhinia guianensis is a typical plant in the Amazon region belonging to the family Leguminosea, used by local populations for the treatment of infectious and renal diseases. Previous work on the plant B. guianensis led to the isolation of substances with anti-inflammatory and analgesic activities. Thus, compounds isolated from B. guianensis with antimicrobial activities had not been identified. Given that there is a possibility of biological activity reported for a given plant being found in the endophytic fungi, we decided to isolate endophytic fungi from B. guianensis and test their antimicrobial activities. The alkaloids known as fumigaclavine C and pseurotin A were isolated by column chromatography and identified by 1D and 2D NMR techniques and mass spectrometry. The alkaloids are first reported as broad-spectrum antibacterial agents with good activity.

• 出版日期2013-9-1