Aging by epigenetics - A consequence of chromatin damage?

作者:Sedivy John M*; Banumathy Gowrishankar; Adams Peter D
来源:Experimental Cell Research, 2008, 314(9): 1909-1917.
DOI:10.1016/j.yexcr.2008.02.023

摘要

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. in some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.

  • 出版日期2008-5-15